The Endocannabinoid Deficiency Theory Explained

The Endocannabinoid Deficiency Theory Explained

Endocannabinoid Deficiency Theory

In our previous post, we touched on the endocannabinoid system and how this neurological network works within our bodies to maintain systematic homeostasis. Cannabinoids work with CB1 and CB2 receptors to aid in regulatory functions concerning inflammation, immune response, metabolic performance, as well as a host of other operations within the human body. As an expansion on this topic, it is important to discuss endocannabinoid deficiency theory in relation to the many health claims that are tied to cannabinoids and CBD use. As always, first and foremost, any health related decisions should be discussed with a doctor, especially if you are being treated with medication for any condition. There are certain enzymes within the body that render CBD incompatible for use with certain prescription medication.

We here at Revexia do the digging in order to have the knowledge to offer insight into questions you might have regarding if CBD is right for you.

What is clinical endocannabinoid deficiency?

Clinical endocannabinoid deficiency theory is a new horizon in CBD research; it might hold the key to unanswered conditions such as autoimmune disease, fibromyalgia, and other widespread systematic disorders.

This theory was first introduced in 2001 and highlights the neurological function, or dysfunction of the cannabinoid receptors in the body. The belief is that a lack of endocannabinoid production in the body, or ineffective receptors contribute to an imbalance in the body. This leads to an ineffective or over reactive immune system, or hyperactive inflammatory response. Current studies examine the function of endocannabinoids in patients with conditions like irritable bowel syndrome and migraines, as well as psychological conditions like anxiety and post-traumatic stress disorder. From the limited studies that have been conducted, there is an indication that introduction of a CBD regimen could be helpful in these cases.

Why does this matter?

Because research has seen so many different health conditions responding favorably to CBD treatment, medical professionals hypothesize that endocannabinoid deficiency could be the underlying commonality. Cannabinoids are unique in that they do not treat diseases themselves; rather they activate regulatory systems in the body that might not be working the way they should. The hypothesis is that these hard to treat diseases could all be a product of some kind of deficiency, merely manifesting itself in different ways.

Neurotransmitter deficiencies are cited as the cause for many diseases such as Parkinson’s, Alzheimer’s, and depression. Science has identified the presence of a chemical imbalance in these conditions, marked by a either a lack of chemicals or hormones, or a failure of the receptors that utilize them.

Because the endocannabinoid system works in areas like inflammation, immunity, and cell function, it naturally fits the attributes of autoimmune diseases. Endocannabinoid deficiency could have the ability to explain the pathology behind functional disorders.  In a study published in 2004 by Neuroendocrinology Letters, endocannabinoid deficiency theory is considered provable, but requires extensive research.

It is already apparent through the few studies that have been done so far that cannabinoids have some kind of impact on many systems in the body. Many have claimed overwhelmingly positive results from CBD use. The discovery of the endocannabinoid system itself was impactful in understanding systematic function. However, what remains to be researched and uncovered is if endocannabinoid deficiency theory can be substantiated as an explanation for so many unexplained disorders.

It is clear however, that this is an avenue that should be explored further, for the sake of so many who face diseases that cannot be solved by current traditional medicine.


If you are interested in trying CBD or just want more information about the endocannabinoid system, feel free to call Revexia anytime at (970) 449-1603, or stop by our storefront at 1724 Topaz Dr. in Loveland.

What is the Endocannabinoid System?

What is the Endocannabinoid System?

What is the endocannabinoid system?

When exploring CBD it is important to understand its biological function and how the compound interacts with the human systems. Many companies and researchers tout CBD as a claimed treatment for many diseases and conditions. However, does the everyday individual know exactly how CBD works in their body and how taking it will affect them? Understanding the endocannabinoid system is important for anyone considering adding CBD to their life.

That sounds fake.

When exploring the function of CBD we hear about this lofty thing called the endocannabinoid system. It seems hard to believe that there is a system in our bodies that is named after a recently popularized and controversial substance. Where is it? Moreover, why is CBD a miracle substance that interacts with it so well?

In an effort to do some myth busting, we have found information that is vital to the understanding of the endocannabinoid system and why CBD plays such an important role in understanding our body’s biological function.

The endocannabinoid system was discovered in 1988.

Until this point, research had been focused on cannabinoids themselves, their chemical structure and their properties. It was not until scientists discovered cannabinoid receptors in the brain of an animal that the scientific community established a substantial connection between cannabinoids and the function of the human body.

In the 1990’s scientists were able to identify endocannabinoids that were organically produced in our cells. The endocannabinoid system is a network of receptors within the neurological pathways of the human body. These receptors are activated by the presence of naturally occurring endocannabinoids produced in our cells. Research shows that these receptors play a huge role in maintaining cellular homeostasis. They affect inflammatory response systems, immune function, metabolism, and so much more.

There are two well-known cannabinoid receptors.

The CB1 receptors are cannabinoid receptors that are housed predominately in the brain and central nervous system. These play a large role in regulation of pain as their signaling function is utilized in various regulatory systems. Research indicates that these receptors have a large impact on executive functioning and suppressing synaptic transmissions. In basic terms, CB1 receptors help decide what signals are important enough to send to the brain. This means that signals like pain, hunger, and inflammation are all regulated by this system.

CB2 receptors are more widespread throughout the body. They are more present in the immune system and hematopoietic system (organs and tissues). They are also present in the brain and nervous system, but less so than CB1 receptors. CB2 receptors aid in immunological responses, including inflammation. The widespread characteristic of this receptor is indicative of its effect on far reaching neurological systems. Conditions happening throughout the entire body are more impacted by the regulation, or dysregulation, of these receptors. For example, CB2 receptors found in the digestive tract are suspected to be involved in chronic inflammatory conditions involving the gut.

CB1 receptors have been identified as heavily impacted by THC, the euphoric cannabinoid compound. This explains why THC works to mitigate pain symptoms and aid in pain management. CBD affects the entire endocannabinoid system, meaning that it works throughout the body in a number of different ways.

CBD has unlocked our knowledge and the potential of this intricate system.

There is a clear association between phytocannabinoids (cannabinoids from plants) and the endocannabinoid system, which bears a similar name. This is no coincidence, especially when you consider that the discovery of this regulatory system was a side effect of CBD research. The topic of current research is how CBD activates this system and allows the body to regulate itself better. CBD does not “cure” these ailments in and of itself. What is being seen and theorized is that cannabinoids work to activate receptors that might not be functioning the way they should. Research is currently being done on other animal species in which an endocannabinoid system has been identified.

Furthermore, cannabinoids are not only found in the cannabis plants. There are many other sources of this naturally occurring substance. Flax seeds, Echinacea, black pepper, and Maca are all examples of sources of phytocannabinoids, however none has been found to contain the volume that Cannabis and Hemp contain. This is especially exciting because it lends even more legitimacy to the research being done on cannabis and the endocannabinoid system.

If you are interested in trying CBD or just want more information about the endocannabinoid system, feel free to call Revexia anytime at (970) 449-1603, or stop by our storefront at 1724 Topaz Dr. in Loveland.