CBD Interaction with Autism

CBD Interaction with Autism

CBD and Autism

People who have autism are generally faced with the reality of numerous medications for a plethora of different accompanying issues. Many parents and people who have autism have turned to CBD as a plant-based alternative to the pharmaceuticals they are prescribed. With CBD products being a newer mainstream concept, research is minimal thus far. With an eye towards education, we have explored and compiled all the information we could find surrounding CBD interaction with autism.

As there is no medication that treats or cures autism, similarly CBD doesn’t treat autism itself, but studies show it can help to alleviate the symptoms that accompany this condition.

Autism

Autism, or autism spectrum disorder (ASD), refers to the range of conditions that affect people through their social skills and communication, and is often characterized by repetitive behaviors and speech and nonverbal communication. This condition is a spectrum disorder, meaning that individuals with ASD can range from mild or moderate symptoms to more severe, requiring constant support.

Areas commonly affected by this condition include gastrointestinal disorders, seizures and sleep disorders. Anxiety, depression and attention deficits are usually present.

People with autism typically have a long list of daily medications, which can cause more problems than they solve. This lends itself to more parents and caregivers turning to CBD for alternative treatment, exploring CBD interaction with autism.

Mental Health

Anxiety and depression are commonalities seen in those diagnosed with autism. Many are put on mood stabilizers to combat these symptoms, which have countless negative side effects.

As of late, cannabis has been claimed as a top contributor for easing anxiety amongst the masses, and recent research has started to back these claims. CB1 receptors have been among the neurological transmitters targeted by anti-anxiety medication, as they play a key role in regulatory systems. Cannabinoids such as CBD function as the direct agonist to these receptors, creating an exciting pathway to aiding in this issue.

A study completed in Israel with children with autism around the age 11 concluded that 47% of these patients had lessened anxiety related symptoms. This is significant because it gives hope to those relying on harsh medications that have previously been their only option.

Another study completed with adults who have anxiety showed just under 80% of patients reported improvement in their anxiety levels after just two months of treatment using this cannabinoid.

Communication is a cornerstone concern for individuals that have autism. Verbal and nonverbal communication is commonly targeted in therapies for autism spectrum disorder. These issues can be directly related to anxiety, therefore affected by the same CB1 receptors that CBD has impact on. In a study completed in Brazil on 18 patients diagnosed with autism, communication was reportedly one of the strongest improvement areas.

Health Problems

People who have autism suffer from numerous health problems associated with this condition. An autism diagnosis is commonly synonymous with gastrointestinal problems, seizures and sleep disorders, among others.

As mentioned in our previous blog, cannabinoids like CBD interact with CB2 receptors to help regulate our body’s homeostasis. CBD interacts with regulatory function of the immune system, which can affect diseases with gastrointestinal symptoms. Studies show that a high CBD intake perpetuates regulation of these functions, decreasing symptoms that accompany gastrointestinal problems.

Seizures are also common in patients with autism. Many studies indicate a positive response from individuals with seizure disorders, with one medication currently on the market derived from cannabis.  Seizures occur due to electrical dissonance in one’s brain. CBD works to decrease the amount of excitatory neurotransmitters released to the brain, which lessons possible risk for a seizure. Understanding this concept, CBD has been worked into the pharmaceutical industry through Epidiolex, the first ever CBD drug approved by the FDA. This was specifically designed to treat people with treatment resistant epilepsy disorders, and the success rates quickly showed substantial reduction in seizures.

Individuals with autism spectrum disorder can be plagued by sleep disorders and dysregulated sleep patterns. Hyperactivity and aggression can stem from these sleep related issues. CBD can help mitigate this through affinity towards the CB1 receptors within our systems help to regulate proper sleep.  In a study conducted in Israel, children with autism were given CBD to treat comorbid symptoms of the condition. Results showed that over 70% of the patients studied had improved sleep habits.

CBD has been touted as a cannabinoid assisting in mental health therapy and specific health issues through anecdotal evidence for a while. The symptoms of autism are directly in line with the commonalities CBD has been claimed to treat. This lends itself to a hypothesis and a hope that alternative treatment for autism spectrum disorder is on the horizon.

Recent research has pointed in the positive direction for those growing wary of the multitude of pharmaceutical drugs associated with an autism diagnosis. As always, consult your doctor regarding CBD interaction with autism before including CBD treatment into your daily regimen when treating symptoms of autism.

CBD and Digestive Health

CBD and Digestive Health

CBD and Digestive Health

Digestive problems seem to be running rampant in today’s health community. Diagnoses like IBD, Crone’s, and leaky gut are becoming more prevalent. Many individuals have seemed to find relief from utilizing CBD in their daily routine, many finding correlation between CBD and digestive health.

The Endocannabinoid system in our bodies helps to regulate a whole host of functions, one of which is the immune system. Our first line of immune defense is our digestive tract, primarily the gut. This is why when we get sick we tend to notice gastrointestinal issues first. Many people with autoimmune diseases not primarily characterized with digestive problems still experience gastrointestinal discomfort. This is because their immune system is not functioning the way it should, thus their gut is not happy with them.

The Immune System

Cannabinoids help to regulate the immune system by interacting with CB2 receptors in our bodies. They activate cannabinoid receptors that aid in homeostasis, making sure our bodies are responding appropriately to different situations. CB2 receptors are found throughout the body, with a great concentration in the gastrointestinal system, here they work to limit unnecessary immune responses. This does not mean that cannabinoids suppress the immune system, it means they allow the immune system to function better, recognizing when immune defense is actually needed and when it is not.

Diseases like IBD and Crone’s are situations in which the immune system in the gut is not working correctly and attacks the body as a foreign body or malicious entity. Those suffering with this disease experience gastrointestinal discomfort and food sensitivities. It is not known exactly what causes this immune system malfunction, but current research indicates it might have a connection with the endocannabinoid system. This would make sense because of the endocannabinoid system’s great influence on the immune system.

The Research

In a study done in 2011, a number of patients with IBD that was resistant to treatment showed marked improvement in symptoms following an introduction of CBD oil into their daily regimen. It is unclear whether or not this was merely based on cannabinoids helping with the symptoms or the underlying issue causing them. However, this is promising to those who experience frustration without relief of their disease.

The most significant improvement seen is in the quality of life. For those with chronic illness, living a normal life with the disease is the hardest part. With limited options for treatment of these inflammatory conditions, CBD offers a viable option for relief. With legalization of cannabinoids from hemp and medical marijuana, more and more patients are turning to alternative treatments.

Crone’s disease is an autoimmune disease that is characterized by inflammation of the digestive tract. Those with this disease often suffer gastrointestinal discomfort and pain. Food sensitivities accompany this illness and often lead to extreme weight loss. In a study that compared the use of CBD to a placebo, the group that consumed cannabis showed more improvement in their symptoms. It is important to note that these results are in comparison to a placebo treatment. However, when considering the alternative medications to Crone’s and their side effects CBD might be a more appealing option.
In many cases, steroids are used to treat chronic inflammation, and when used long term they can cause diabetes, high blood pressure, and higher risks of infection.

While there is limited evidence that shows the validity of actual treatment of diseases using cannabinoids, the improvement in symptoms is enough to give hope. As with any medical decision, be sure to consult with your doctor if you are considering adding CBD to your diet. Consider any other medications you are taking as some are metabolized in a way that is not compatible with CBD.

For any questions or to try CBD out for yourself feel free to call us here at Revexia: (970) 449-1603, or stop by our storefront located at 1724 Topaz Drive, Loveland, CO 80537.

The Endocannabinoid Deficiency Theory Explained

The Endocannabinoid Deficiency Theory Explained

Endocannabinoid Deficiency Theory

In our previous post, we touched on the endocannabinoid system and how this neurological network works within our bodies to maintain systematic homeostasis. Cannabinoids work with CB1 and CB2 receptors to aid in regulatory functions concerning inflammation, immune response, metabolic performance, as well as a host of other operations within the human body. As an expansion on this topic, it is important to discuss endocannabinoid deficiency theory in relation to the many health claims that are tied to cannabinoids and CBD use. As always, first and foremost, any health related decisions should be discussed with a doctor, especially if you are being treated with medication for any condition. There are certain enzymes within the body that render CBD incompatible for use with certain prescription medication.

We here at Revexia do the digging in order to have the knowledge to offer insight into questions you might have regarding if CBD is right for you.

What is clinical endocannabinoid deficiency?

Clinical endocannabinoid deficiency theory is a new horizon in CBD research; it might hold the key to unanswered conditions such as autoimmune disease, fibromyalgia, and other widespread systematic disorders.

This theory was first introduced in 2001 and highlights the neurological function, or dysfunction of the cannabinoid receptors in the body. The belief is that a lack of endocannabinoid production in the body, or ineffective receptors contribute to an imbalance in the body. This leads to an ineffective or over reactive immune system, or hyperactive inflammatory response. Current studies examine the function of endocannabinoids in patients with conditions like irritable bowel syndrome and migraines, as well as psychological conditions like anxiety and post-traumatic stress disorder. From the limited studies that have been conducted, there is an indication that introduction of a CBD regimen could be helpful in these cases.

Why does this matter?

Because research has seen so many different health conditions responding favorably to CBD treatment, medical professionals hypothesize that endocannabinoid deficiency could be the underlying commonality. Cannabinoids are unique in that they do not treat diseases themselves; rather they activate regulatory systems in the body that might not be working the way they should. The hypothesis is that these hard to treat diseases could all be a product of some kind of deficiency, merely manifesting itself in different ways.

Neurotransmitter deficiencies are cited as the cause for many diseases such as Parkinson’s, Alzheimer’s, and depression. Science has identified the presence of a chemical imbalance in these conditions, marked by a either a lack of chemicals or hormones, or a failure of the receptors that utilize them.

Because the endocannabinoid system works in areas like inflammation, immunity, and cell function, it naturally fits the attributes of autoimmune diseases. Endocannabinoid deficiency could have the ability to explain the pathology behind functional disorders.  In a study published in 2004 by Neuroendocrinology Letters, endocannabinoid deficiency theory is considered provable, but requires extensive research.

It is already apparent through the few studies that have been done so far that cannabinoids have some kind of impact on many systems in the body. Many have claimed overwhelmingly positive results from CBD use. The discovery of the endocannabinoid system itself was impactful in understanding systematic function. However, what remains to be researched and uncovered is if endocannabinoid deficiency theory can be substantiated as an explanation for so many unexplained disorders.

It is clear however, that this is an avenue that should be explored further, for the sake of so many who face diseases that cannot be solved by current traditional medicine.

 

If you are interested in trying CBD or just want more information about the endocannabinoid system, feel free to call Revexia anytime at (970) 449-1603, or stop by our storefront at 1724 Topaz Dr. in Loveland.